Tissue homeostasis is dependent on the spatially controlled localization of specific cell types and the correct composition of the extracellular stroma. Integrin mediated adhesions, in conjunction with the actin cytoskeleton, allow cells to sense the stiffness of the surrounding extra-cellular matrix (ECM). Conversely, cells exert acto-myosin and integrin dependent forces to remodel and organize the surrounding ECM. I will describe our recent findings on how integrin mediated adhesions regulate cell morphology, behaviour and patterning in human pluripotent stem cells as well as during branching morphogenesis in the developing mammary gland.

In cancer, stiffening of the tumor stroma is considered as an instrumental contributor to tumor progression. However, the mechanisms how cancer cells regulate this process and conversely the mechanisms how the stromal ECM regulates cancer progression are not fully understood. I will describe our recent findings on the interrelationship between cancer cell mediated ECM remodelling and ECM induced mechanochemical signals effecting cancer cells.